Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12747 |
ROCK2-IN-2
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK2-IN-2 是 ROCK2 的特异性抑制剂(IC50 <1 μM)。 | |||
T60924 |
Verosudil
AR-12286 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Verosudil (AR-12286) 是一种高效的 Rho 激酶 (ROCK) 抑制剂,对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 可逆转类固醇诱导的小鼠眼内压,可通过增加眼房水通过小梁网流出来减缓眼压。 | |||
T61497 |
Rho-Kinase-IN-2
|
||
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC50) of 3 nM. This compound is of potential interest for further investigations in the field of Huntington's disease research [1]. | |||
T26821 | BIPM | ||
BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits phosphorylation of cofilin, a regula |